![The fact that this slight change in study design yielded opp...](https://readwise-assets.s3.amazonaws.com/static/images/article3.5c705a01b476.png)
Josh BeckmanThe fact that this slight change in study design yielded opposite results suggests the results aren’t reliable. If you tweak your design parameters slightly, without a clear hypothesis-driven reason to do so, and the whole thing falls apart, that suggests your results may not be real but rather are just statistical noise.
✉️Katelyn Jetelina and Kristen Panthagani, MD, PhD from Your Local EpidemiologistEvolution of Florida Vaccine Analysis